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The use of hydroxocobalamin became first line due to its low adverse risk profile, rapid onset of action, and ease of use in the prehospital setting

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Peer-reviewed research has investigated AOD-9604 across animal models, ex vivo adipose tissue assays, and human clinical trials , with published studies appearing in journals including Endocrinology , the American Journal of Physiology Endocrinology and Metabolism , and Hormone Research

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